Meta-análisis de estudios prospectivos sobre el consumo de café y mortalidad por todas las causas, cáncer y enfermedades cardiovasculares.

27-04-2017

Se adelantó una revisión sistemática y meta-análisis con el objetivo de evaluar la relación entre el consumo de café y la mortalidad por todas las causas, por cáncer y por enfermedades cardiovasculares. La búsqueda se llevó a cabo en las bases de datos PubMed y Embase, y se complementó buscando en las referencias de los artículos encontrados. El trabajo se realizó siguiendo los parámetros de las guías MOOSE (Meta-Análisis of Observational Studies in Epidemiology). Se incluyeron estudios observacionales prospectivos, escritos en inglés y adelantados en humanos. Tres autores extrajeron los datos por separado y cuando hubo discrepancias fueron discutidas y solventadas. Para el análisis estadístico se calcularon los riesgos relativos agrupados (RRa) para la mayor categoría de consumo de café en comparación con el menor consumo, empleando el modelo de efectos aleatorios (random-effect model). La heterogeneidad entre los estudios se calculó mediante las pruebas de X2 e I2, estableciendo un valor de p

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