Estudio sobre el café y su incidencia en el riesgo de cáncer de próstata y mortalidad por cáncer de próstata en Suecia

27-04-2017

Varios estudios epidemiológicos han vinculado el consumo de café con una disminución significativa del riesgo de padecer cáncer de próstata avanzado y letal. El objetivo de este trabajo es explorar la asociación entre el consumo de café y el riesgo de cáncer de próstata mediante un estudio de casos y controles en el marco de la investigación Cancer of the Prostate in Sweden. Se reclutaron 1499 casos y 1112 controles. Se estudió el riesgo general para cáncer de próstata así como el riesgo de cáncer letal, avanzado, localizado, de alto grado, grado 7 y de bajo grado. El consumo de café no resultó asociado con el riesgo general de cáncer de próstata. El riesgo de cáncer de próstata fatal mostró una relación inversa aunque no estadísticamente significativa, para hombres que consumen >5 tazas de café al día (OR=0,64, 95%IC 0,34-1,19 tendencia de p= 0,81). El consumo más alto de café estuvo asociado con un menor riesgo de enfermedad avanzada, sin embargo esta relación no fue estadísticamente significativa (OR= 0,73, 95%IC 0,41-1,30 tendencia de p=0,98). También una asociación no significativa entre el consumo más alto de café y un menor riesgo de cáncer de alto grado (OR= 0,5, 95% IC 26-0.98, tendencia p= 0,13). El riesgo de cáncer localizado, de grado 7, y de bajo grado no resultaron asociados al consumo de café. Este estudio contribuye con alguna evidencia a una asociación inversa entre el consumo de café y el cáncer de próstata de alto grado y letal.

Kathryn M. Wilson, Katarina Bälter, Elisabeth Möller, Hans-Olov Adami, Ove Andrén, Swen-Olof Andersson, Henrik Grönberg, Lorelei A. Mucci. Coffee and risk of prostate cancer incidence and mortality in the Cancer of the Prostate in Sweden Study. August 2013, Volume 24, Issue 8, pp 1575-1581, DOI 10.1007/s10552-013-0234-9, Online ISSN 1573-7225.

  1. Wilson KM, Kasperzyk JL, Rider JR, Kenfield S, van Dam RM, Stampfer MJ, Giovannucci E, Mucci LA (2011) Coffee consumption and prostate cancer risk and progression in the Health Professionals Follow-up Study. J Natl Cancer Inst 103(11):876–884 CrossRef
  2. Svilaas A, Sakhi AK, Andersen LF, Svilaas T, Strom EC, Jacobs DR Jr et al (2004) Intakes of antioxidants in coffee, wine, and vegetables are correlated with plasma carotenoids in humans. J Nutr 134(3):562–567
  3. Pulido R, Hernandez-Garcia M, Saura-Calixto F (2003) Contribution of beverages to the intake of lipophilic and hydrophilic antioxidants in the Spanish diet. Eur J Clin Nutr 57(10):1275–1282 CrossRef
  4. Kempf K, Herder C, Erlund I, Kolb H, Martin S, Carstensen M et al (2010) Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial. Am J Clin Nutr 91(4):950–957 CrossRef
  5. Tunnicliffe JM, Shearer J (2008) Coffee, glucose homeostasis, and insulin resistance: physiological mechanisms and mediators. Appl Physiol Nutr Metab 33(6):1290–1300 CrossRef
  6. Svartberg J, Midtby M, Bonaa KH, Sundsfjord J, Joakimsen RM, Jorde R (2003) The associations of age, lifestyle factors and chronic disease with testosterone in men: The Tromso study. Eur J Endocrinol 149(2):145–152 CrossRef
  7. Hsieh CC, Signorello LB, Lipworth L, Lagiou P, Mantzoros CS, Trichopoulos D (1998) Predictors of sex hormone levels among the elderly: a study in Greece. J Clin Epidemiol 51(10):837–841 CrossRef
  8. Ma J, Li H, Giovannucci E, Mucci L, Qiu W, Nguyen PL et al (2008) Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis. Lancet Oncol 9(11):1039–1047 CrossRef
  9. Hammarsten J, Hogstedt B (2005) Hyperinsulinaemia: a prospective risk factor for lethal clinical prostate cancer. Eur J Cancer 41(18):2887–2895 CrossRef
  10. Lehrer S, Diamond EJ, Stagger S, Stone NN, Stock RG (2002) Increased serum insulin associated with increased risk of prostate cancer recurrence. Prostate 50(1):1–3 CrossRef
  11. De Marzo AM, Nakai Y, Nelson WG (2007) Inflammation, atrophy, and prostate carcinogenesis. Urol Oncol 25(5):398–400 CrossRef
  12. Bardia A, Platz EA, Yegnasubramanian S, De Marzo AM, Nelson WG (2009) Anti-inflammatory drugs, antioxidants, and prostate cancer prevention. Curr Opin Pharmacol 9(4):419–426 CrossRef
  13. Schroder FH, van Weerden WM (2009) Prostate cancer—chemoprevention. Eur J Cancer 45(Suppl 1):355–359 CrossRef
  14. Endogenous Hormones and Prostate Cancer Collaborative Group, Roddam AW, Allen NE, Appleby P, Key TJ (2008) Endogenous sex hormones and prostate cancer: a collaborative analysis of 18 prospective studies. J Natl Cancer Inst 100(3):170–183 CrossRef
  15. Platz EA, Giovannucci E (2004) The epidemiology of sex steroid hormones and their signaling and metabolic pathways in the etiology of prostate cancer. J Steroid Biochem Mol Biol 92(4):237–253 CrossRef
  16. Nomura A, Heilbrun LK, Stemmermann GN (1986) Prospective study of coffee consumption and the risk of cancer. J Natl Cancer Inst 76(4):587–590
  17. Severson RK, Nomura AM, Grove JS, Stemmermann GN (1989) A prospective study of demographics, diet, and prostate cancer among men of Japanese ancestry in Hawaii. Cancer Res 49(7):1857–1860
  18. Le Marchand L, Kolonel LN, Wilkens LR, Myers BC, Hirohata T (1994) Animal fat consumption and prostate cancer: a prospective study in Hawaii. Epidemiology 5(3):276–282 CrossRef
  19. Jacobsen BK, Bjelke E, Kvale G, Heuch I (1986) Coffee drinking, mortality, and cancer incidence: results from a Norwegian prospective study. J Natl Cancer Inst 76(5):823–831
  20. Slattery ML, West DW (1993) Smoking, alcohol, coffee, tea, caffeine, and theobromine: risk of prostate cancer in Utah (United States). Cancer Causes Control 4(6):559–563 CrossRef
  21. Jain MG, Hislop GT, Howe GR, Burch JD, Ghadirian P (1998) Alcohol and other beverage use and prostate cancer risk among Canadian men. Int J Cancer 78(6):707–711 CrossRef
  22. Villeneuve PJ, Johnson KC, Kreiger N, Mao Y (1999) Risk factors for prostate cancer: results from the Canadian National Enhanced Cancer Surveillance System. The Canadian Cancer Registries Epidemiology Research Group. Cancer Causes Control 10(5):355–367 CrossRef
  23. Sharpe CR, Siemiatycki J (2002) Consumption of non-alcoholic beverages and prostate cancer risk. Eur J Cancer Prev 11(5):497–501 CrossRef
  24. Hsieh CC, Thanos A, Mitropoulos D, Deliveliotis C, Mantzoros CS, Trichopoulos D (1999) Risk factors for prostate cancer: a case–control study in Greece. Int J Cancer 80(5):699–703 CrossRef
  25. Chen C, Lewis SK, Voigt L, Fitzpatrick A, Plymate SR, Weiss NS (2005) Prostate carcinoma incidence in relation to prediagnostic circulating levels of insulin-like growth factor I, insulin-like growth factor binding protein 3, and insulin. Cancer 103(1):76–84 CrossRef
  26. Gallus S, Foschi R, Talamini R, Altieri A, Negri E, Franceschi S et al (2007) Risk factors for prostate cancer in men aged less than 60 years: a case–control study from Italy. Urology 70(6):1121–1126 CrossRef
  27. Ellison LF (2000) Tea and other beverage consumption and prostate cancer risk: a Canadian retrospective cohort study. Eur J Cancer Prev 9(2):125–130 CrossRef
  28. Gronberg H, Damber L, Damber JE (1996) Total food consumption and body mass index in relation to prostate cancer risk: a case–control study in Sweden with prospectively collected exposure data. J Urol 155(3):969–974 CrossRef
  29. Fincham SM, Hill GB, Hanson J, Wijayasinghe C (1990) Epidemiology of prostatic cancer: a case–control study. Prostate 17(3):189–206 CrossRef
  30. Talamini R, Franceschi S, La Vecchia C, Serraino D, Barra S, Negri E (1992) Diet and prostatic cancer: a case–control study in northern Italy. Nutr Cancer 18(3):277–286 CrossRef
  31. Park CH, Myung SK, Kim TY, Seo HG, Jeon YJ, Kim Y (2010) Coffee consumption and risk of prostate cancer: a meta-analysis of epidemiological studies. BJU Int 106(6):762–769 CrossRef
  32. Yu X, Bao Z, Zou J, Dong J (2011) Coffee consumption and risk of cancers: a meta-analysis of cohort studies. BMC Cancer 11(1):96–106CrossRef
  33. Phillips RL, Snowdon DA (1983) Association of meat and coffee use with cancers of the large bowel, breast, and prostate among Seventh-Day Adventists: preliminary results. Cancer Res 43(5 Suppl):2403s–2408s
  34. Hsing AW, McLaughlin JK, Schuman LM, Bjelke E, Gridley G, Wacholder S et al (1990) Diet, tobacco use, and fatal prostate cancer: results from the Lutheran Brotherhood Cohort Study. Cancer Res 50(21):6836–6840
  35. Shafique K, McLoone P, Qureshi K, Leung H, Hart C, Morrison DS (2012) Coffee consumption and prostate cancer risk: further evidence for inverse relationship. Nutr J 11(1):42–48 CrossRef
  36. Arab L, Su LJ, Steck SE, Ang A, Fontham ETH, Bensen JT, Mohler JL (2012) Coffee consumption and prostate cancer aggressiveness among African and Caucasian Americans in a population-based study. Nutr Cancer 64(5):637–642 CrossRef
  37. Hedelin M, Klint A, Chang ET, Bellocco R, Johansson JE, Andersson SO et al (2006) Dietary phytoestrogen, serum enterolactone and risk of prostate cancer: The Cancer Prostate Sweden Study (Sweden). Cancer Causes Control 17(2):169–180 CrossRef
  38. Khani BR, Ye W, Terry P, Wolk A (2004) Reproducibility and validity of major dietary patterns among Swedish women assessed with a food-frequency questionnaire. J Nutr 134(6):1541–1545
  39. Stark JR, Perner S, Stampfer MJ, Sinnott JA, Finn S, Eisenstein AS et al (2009) Gleason score and lethal prostate cancer: does 3 + 4 = 4 + 3? J Clin Oncol 27(21):3459–3464 CrossRef
  • 0
  • 188