El efecto protector del consumo de café en el riesgo de melanoma cutáneo y el rol de los polimorfismos GSTM1 y GSTT1.

27-04-2017

Este estudio de casos y controles llevado a cabo en el área de hospitalización de un centro de salud en Roma, Italia, examinó la asociación entre el consumo de café, el melanoma cutáneo y los polimorfismos GSTM1 y GSTT1. El estudio contó con 304 casos (pacientes con melanoma) y 305 controles (pacientes sanos). Se recolectó información sobre las características socio-demográficas de cada uno de los participantes, historia médica, exposición al sol, características pigmentarías y dieta, y se empleó regresión logística para estimar los OR y los IC. Después de ajustar por sexo, edad, educación, color de pelo, lunares comunes, fototipo de la piel y episodios de quemaduras de piel en la infancia, los resultados evidenciaron que una alta frecuencia de consumo de café (más de una vez al día), comparada con una baja frecuencia (siete o menos veces a la semana), es factor protector contra el melanoma cutáneo (OR 0,46; IC 95 % 0,31-0,68). Cuando se estratificó por los genotipos GSTM1 y GSTT1, el efecto protector del café fue extremadamente alto para los sujetos sin ninguno de los dos polimorfismos (OR 0,01; IC 95 % 0,0003-0,54). Los investigadores concluyeron que el consumo de café protege contra el melanoma, particularmente a aquellos con deleción homocigota de GSTM1 y GSTT1.

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