El consumo de un tipo de café griego hervido se asocia con mejoría de la función endotelial: el estudio Ikaria

28-04-2017

Un estudio observacional transversal fue realizado con el objetivo de explorar la asociación entre el consumo crónico de café y la función endotelial en adultos mayores de la isla de Ikaria, Grecia. Se incluyeron 142 pacientes de 61-99 años, y se aplicó una encuesta de hábitos alimenticios. El consumo de café fue clasificado como bajo (450ml/día). La función endotelial fue evaluada mediante ultrasonido estimando la dilatación de flujo (DF). Para el análisis estadístico se empleó una prueba de t de Student. Se adelantó también una regresión logística lineal ajustando por varios confusores. Se observó un incremento linear entre la DF y el consumo de café (bajo: 4,33 +- 2,51% vs moderado: 5,39 +- 3,09% vs alto: 6,47 +- 2,72%; p=0,032). Así mismo, los sujetos que consumían principalmente café griego tuvieron una DF significativamente mayor en comparación con aquellos que consumían otros tipos de café (p=0,035). En este estudio, el consumo crónico de café se asoció con una mejor función endotelial.

Siasos G, Oikonomou E, Chrysohoou C, Tousoulis D, Panagiotakos D, Zaromitidou M. Consumption of a boiled Greek type of coffee is associated with improved endothelial function: the Ikaria study.Vasc Med. 2013 Apr;18(2):55-62.

1. LaCroix AZ, Mead LA, Liang KY, et al. Coffee consumption and the incidence of coronary heart disease. N Engl J Med 1986; 315: 977–982.

2. Panagiotakos DB, Pitsavos C, Chrysohoou C, et al. The J-shaped effect of coffee consumption on the risk of developing acute coronary syndromes: The CARDIO2000 case– control study. J Nutr 2003; 133: 3228–3232.

3. Vlachopoulos C, Panagiotakos D, Ioakeimidis N, et al. Chronic coffee consumption has a detrimental effect on aortic stiffness and wave reflections. Am J Clin Nutr 2005; 81: 1307–1312.

4. Karatzis E, Papaioannou TG, Aznaouridis K, et al. Acute effects of caffeine on blood pressure and wave reflections in healthy subjects: Should we consider monitoring central blood pressure? Int J Cardiol 2005; 98: 425–430.

5. Buscemi S, Verga S, Batsis JA, et al. Dose-dependent effects of decaffeinated coffee on endothelial function in healthy subjects. Eur J Clin Nutr 2009; 63: 1200–1205.

6. De Koning Gans JM, Uiterwaal CS, van der Schouw YT, et al. Tea and coffee consumption and cardiovascular morbidity and mortality. Arterioscler Thromb Vasc Biol 2010; 30: 1665–1671.

7. Greenberg JA, Chow G, Ziegelstein RC. Caffeinated coffee consumption, cardiovascular disease, and heart valve disease in the elderly (from the Framingham Study). Am J Cardiol 2008; 102: 1502–1508.

8. Zucchi R, Ronca-Testoni S. The sarcoplasmic reticulum Ca2+ channel/ryanodine receptor: Modulation by endogenous effectors, drugs and disease states. Pharmacol Rev 1997; 49: 1–51.

9. Spyridopoulos I, Fichtlscherer S, Popp R, et al. Caffeine enhances endothelial repair by an AMPK-dependent mechanism. Arterioscler Thromb Vasc Biol 2008; 28: 1967–1974.

10. Celermajer DS. Endothelial dysfunction: Does it matter? Is it reversible? J Am Coll Cardiol 1997; 30: 325–333.

11. Tousoulis D, Charakida M, Stefanadis C. Endothelial function and inflammation in coronary artery disease. Heart 2006; 92: 441–444.

12. Heffernan KS, Karas RH, Patvardhan EA, et al. Endotheliumdependent vasodilation is associated with exercise capacity in smokers and non-smokers. Vasc Med 2010; 15: 119–125.

13. Onkelinx S, Cornelissen V, Goetschalckx K, et al. Reproducibility of different methods to measure the endothelial function. Vasc Med 2012; 17: 79–84.

14. Kuvin JT, Patel AR, Sliney KA, et al. Peripheral vascular endothelial function testing as a noninvasive indicator of coronary artery disease. J Am Coll Cardiol 2001; 38: 1843–1849.

15. Yeboah J, Crouse JR, Hsu FC, et al. Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: The Cardiovascular Health Study. Circulation 2007; 115: 2390–2397.

16. Stefanadis CI. Unveiling the secrets of longevity: The Ikaria study. Hellenic J Cardiol 2011; 52: 479–480.

17. Panagiotakos DB, Chrysohoou C, Siasos G, et al. Sociodemographic and lifestyle statistics of oldest old people (>80 years) living in Ikaria island: The Ikaria study. Cardiol Res Pract 2011; 2011: 679187.

18. Oikonomou E, Chrysohoou C, Tsiachris D, et al. Gender variation of exercise-induced anti-arrhythmic protection: The Ikaria Study. QJM 2011; 104: 1035–1043.

19. Chrysohoou C, Tsitsinakis G, Siassos G, et al. Fish consumption moderates depressive symptomatology in elderly men and women from the IKARIA Study. Cardiol Res Pract 2011; 2011: 219578.

20. Tsiachris D, Chrysohoou C, Oikonomou E, et al. Distinct role of electrocardiographic criteria in echocardiographic diagnosis of left ventricular hypertrophy according to age, in the general population: The Ikaria Study. J Hypertens 2011; 29: 1624–1632.

21. Cornelis MC, El-Sohemy A. Coffee, caffeine, and coronary heart disease. Curr Opin Lipidol 2007; 18: 13–19. 22. Ranheim T, Halvorsen B. Coffee consumption and human health—beneficial or detrimental? Mechanisms for effects of coffee consumption on different risk factors for cardiovascular disease and type 2 diabetes mellitus. Mol Nutr Food Res 2005; 49: 274–284.

23. Bunker ML, McWilliams M. Caffeine content of common beverages. J Am Diet Assoc 1979; 74: 28–32.

24. Siasos G, Tousoulis D, Vlachopoulos C, et al. The impact of oral L-arginine supplementation on acute smoking-induced endothelial injury and arterial performance. Am J Hypertens 2009; 22: 586–592.

25. Lekakis J, Abraham P, Balbarini A, et al. Methods for evaluating endothelial function: A position statement from the European Society of Cardiology Working Group on Peripheral Circulation. Eur J Cardiovasc Prev Rehabil 2011; 18: 775–789.

26. Echeverri D, Montes FR, Cabrera M, et al. Caffeine’s vascular mechanisms of action. Int J Vasc Med 2010; 2010: 834060.

27. Murase T, Misawa K, Minegishi Y, et al. Coffee polyphenols suppress diet-induced body fat accumulation by downregulating SREBP-1c and related molecules in C57BL/6J mice. Am J Physiol Endocrinol Metab 2011; 300: E122–133.

28. Baylin A, Hernandez-Diaz S, Kabagambe EK, et al. Transient exposure to coffee as a trigger of a first nonfatal myocardial infarction. Epidemiology 2006; 17: 506–511.

29. Panagiotakos DB, Pitsavos C, Zeimbekis A, et al. The association between lifestyle-related factors and plasma homocysteine levels in healthy individuals from the ‘ATTICA’ Study. Int J Cardiol 2005; 98: 471 477.

30. Jee SH, He J, Appel LJ, et al. Coffee consumption and serum lipids: A meta-analysis of randomized controlled clinical trials. Am J Epidemiol 2001; 153: 353–362.

31. Noordzij M, Uiterwaal CS, Arends LR, et al. Blood pressure response to chronic intake of coffee and caffeine: A metaanalysis of randomized controlled trials. J Hypertens 2005; 23: 921–928.

32. Vlachopoulos C, Kosmopoulou F, Panagiotakos D, et al. Smoking and caffeine have a synergistic detrimental effect on aortic stiffness and wave reflections. J Am Coll Cardiol 2004; 44: 1911–1917.

33. Vlachopoulos CV, Vyssoulis GG, Alexopoulos NA, et al. Effect of chronic coffee consumption on aortic stiffness and wave reflections in hypertensive patients. Eur J Clin Nutr 2007; 61: 796–802.

34. Hartley TR, Lovallo WR, Whitsett TL. Cardiovascular effects of caffeine in men and women. Am J Cardiol 2004; 93: 1022–1026.

35. Wennmalm A, Wennmalm M. Coffee, catecholamines and cardiac arrhythmia. Clin Physiol 1989; 9: 201–206.

36. Klag MJ, Mead LA, LaCroix AZ, et al. Coffee intake and coronary heart disease. Ann Epidemiol 1994; 4: 425–433.

37. Zhang WL, Lopez-Garcia E, Li TY, et al. Coffee consumption and risk of cardiovascular events and all-cause mortality among women with type 2 diabetes. Diabetologia 2009; 52: 810–817.

38. Ross R. The pathogenesis of atherosclerosis: A perspective for the 1990s. Nature 1993; 362: 801–809.

39. Quinaglia T, Martins LC, Figueiredo VN, et al. Non-dipping pattern relates to endothelial dysfunction in patients with uncontrolled resistant hypertension. J Hum Hypertens 2011; 25: 656–664.

40. Hasegawa T, Boden-Albala B, Eguchi K, et al. Impaired flow-mediated vasodilatation is associated with increased left ventricular mass in a multiethnic population. The Northern Manhattan Study. Am J Hypertens 2010; 23: 413–419.

41. Lopez-Garcia E, van Dam RM, Qi L, et al. Coffee consumption and markers of inflammation and endothelial dysfunction in healthy and diabetic women. Am J Clin Nutr 2006; 84: 888–893.

42. Bidel S, Hu G, Sundvall J, et al. Effects of coffee consumption on glucose tolerance, serum glucose and insulin levels – A cross-sectional analysis. Horm Metab Res 2006; 38: 38–43.

  • 0
  • 2120