El consumo de café y el riesgo de cáncer de próstata: el Estudio de Cohorte Ohsaki

27-04-2017

Se adelantó un estudio observacional con el objetivo de explorar la relación entre el consumo de café y el riesgo de cáncer de próstata. Se escogió un diseño de cohorte prospectivo en la ciudad Ohsaki, Japón, incluyendo 18853 hombres entre 40-79 años. El consumo de café fue evaluado empleando un cuestionario validado auto-diligenciado. Se empleó un modelo de regresión de riesgos proporcionales de Cox para estimar las razones de riesgo con un nivel de significancia de 95%.También se incluyeron en el análisis variables confusoras como edad, IMC, tabaquismo, consumo de alcohol y estadio de cáncer de próstata, mediante estratificación. Durante 11 años de seguimiento (del 1 de enero de 1995 al 31 de diciembre de 2005), 318 casos incidentes de cáncer de próstata fueron detectados. Se evidenció una asociación inversa y significativa entre el consumo de café y el riesgo de cáncer de próstata. Comparado con no consumo de café, la razón de riesgos ajustada fue 0.81 (IC 95%: 0.61-1.07) para los consumidores ocasionales de café , 0.73 (IC 95%: 0.53-1.00) para los consumidores de 1-2 tazas/día, y 0.63 (IC 95%: 0.39-1.00) para consumidores de >=3 tazas por día, respectivamente (0.02). En conclusión, este estudio de cohorte evidenció una relación inversa entre el consumo de café y la incidencia de cáncer de próstata.

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