El café previene eventos tempranos en pacientes con cáncer de mama tratados con tamoxifeno y modula el estado de los receptores hormonales

27-04-2017

Este trabajo tuvo como objetivo investigar el impacto del consumo de café en las características tumorales y riesgo de eventos tempranos en relación con el tratamiento de cáncer de seno, estimando la presencia de genotipos CYP1A2 Y CYP2C8, la cual podría confundir la asociación. Un estudio de cohorte fue adelantado aplicando un cuestionario sobre estilo de vida a 634 pacientes en el sur de Suecia quienes iban a ser intervenidos quirúrgicamente. La presencia de los citocromos CYP1A2*1F y CYP2C8*3 fue genotipificada en cada paciente. Los datos clínicos y características del tumor fueron obtenidos de los registros de los pacientes, registros demográficos, e informes de patología. El consumo de café fue clasificado en las siguientes categorías: bajo (0-1 tazas/día), moderado (2-4 tazas/día), o alto (5 + tazas/día). La proporción de tumores receptor de estrógeno negativos (ER-) aumentó con el aumento de consumo de café (p = 0.042). El consumo moderado a alto fue asociado con una frecuencia inferior en el status de receptor discordante (ER + PgR-) OR 0.38 (0.23-0.63) comparado con un consumo bajo de café. El tiempo de seguimiento promedio fue 4.92 (IQR 3.01-6.42) años. Los pacientes tratados con tamoxifeno con tumores ER + (n = 310) que consumieron dos o más tazas/día presentan una disminución del riesgo considerable de eventos tempranos comparados con pacientes cuyo consumo fue bajo, HR ajustado fue 0.40 (0.19-0.83). El consumo bajo combinado con al menos un alelo CYP1A2*1F C (n = 35) o CYP2C8*3 (n = 13) fue asociado con un alto riesgo para eventos tempranos en pacientes tratados con tamoxifeno comparado con otros pacientes tratados con tamoxifeno, HR ajustado 3.49 (1.54-7.91) y 6.15 (2.46-15.36), respectivamente. CONCLUSIÓN: Un consumo moderado a alto de café está asociado con una reducción significativa de riesgo de eventos tempranos en pacientes tratados con tamoxifeno y con status de receptor hormonal modificado. De ser confirmado, nuevas recomendaciones en cuanto al consumo de café durante el tratamiento con tamoxifeno podrían ser realizadas.

Maria Simonsson, Viktoria Söderlind, Maria Henningson, Maria Hjertberg, Carsten Rose, Christian Ingvar, Helena Jernström. Coffee prevents early events in tamoxifen-treated breast cancer patients and modulates hormone receptor status. May 2013, Volume 24, Issue 5, pp 929-940 Online ISSN 1573-7225

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