Asociación del consumo de Té y Café con riesgo de cáncer de próstata

27-04-2017

Se adelantó un estudio de casos y controles con el objetivo de explorar la relación entre el consumo de té y café con el riesgo de cáncer de próstata (CP). La investigación se realizó en King County, Washington, EE.UU. Se incluyeron 1001 casos de CP diagnosticados entre 2002-2005. 942 controles fueron incluidos pareando por grupos etarios de 5 años. Una regresión logística no condicionada fue utilizada para estimar la Razón de Momios (odds ratio OR) empleando intervalos de confianza del 95 % (IC). Se consideraron variables confusoras que pudieran modificar la asociación. Entre los controles, 19 % y 58 % consumían al menos una taza por día de té y café, respectivamente. Con respecto al consumo de té, se incluyeron 892 casos y 863 controles. Para los hombres, comparando la categoría más alta de consumo con la más baja (≥2 tazas/día contra ≤1 taza/semana) se observó una asociación significativa entre el consumo de té y una reducción del riesgo de CP (OR ajustado 0.63 IC 95%: 0.45, 0.90; P para tendencia = 0.02). Las estimaciones de riesgo no variaron considerablemente según el grado de Gleason o el estadio de la enfermedad. Por otro lado, el consumo de café no resultó asociado con el riesgo de CP total o en subgrupos según grado del tumor o estadio. En conclusión, en este estudio el consumo de té resulto inversamente asociado con el riesgo de CP.

Milan S. Geybels, Marian L. Neuhouser, Janet L. Stanford. Associations of tea and coffee consumption with prostate cancer risk. May 2013, Volume 24, Issue 5, pp 941-948, DOI 10.1007/s10552-013-0170-8, Online ISSN 1573-7225

  1. Higdon JV, Frei B (2003) Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions. Crit Rev Food Sci Nutr 43:89–143 CrossRef
  2. Yang CS, Wang H, Li GX, Yang Z, Guan F, Jin H (2011) Cancer prevention by tea: evidence from laboratory studies. Pharmacol Res 64:113–122 CrossRef
  3. Arab L (2010) Epidemiologic evidence on coffee and cancer. Nutr Cancer 62:271–283 CrossRef
  4. Farah A, Monteiro M, Donangelo CM, Lafay S (2008) Chlorogenic acids from green coffee extract are highly bioavailable in humans. J Nutr 138:2309–2315 CrossRef
  5. Higdon JV, Frei B (2006) Coffee and health: a review of recent human research. Crit Rev Food Sci Nutr 46:101–123 CrossRef
  6. Yang H, Rouse J, Lukes L et al (2004) Caffeine suppresses metastasis in a transgenic mouse model: a prototype molecule for prophylaxis of metastasis. Clin Exp Metastasis 21:719–735 CrossRef
  7. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61:69–90 CrossRef
  8. Geybels MS, Verhage BA, Arts IC, van Schooten FJ, Bausch RA, van den Brandt PA (2012) Dietary flavonoid intake, black tea consumption, and risk of overall and advanced stage prostate cancer. Am J Epidemiol. Accepted for publication
  9. Wilson KM, Kasperzyk JL, Rider JR et al (2011) Coffee consumption and prostate cancer risk and progression in the health professionals follow-up study. J Natl Cancer Inst 103:876–884 CrossRef
  10. Park CH, Myung SK, Kim TY, Seo HG, Jeon YJ, Kim Y (2010) Coffee consumption and risk of prostate cancer: a meta-analysis of epidemiological studies. BJU Int 106:762–769 CrossRef
  11. Zheng J, Yang B, Huang T, Yu Y, Yang J, Li D (2011) Green tea and black tea consumption and prostate cancer risk: an exploratory meta-analysis of observational studies. Nutr Cancer 63:663–672 CrossRef
  12. Agalliu I, Salinas CA, Hansten PD, Ostrander EA, Stanford JL (2008) Statin use and risk of prostate cancer: results from a population-based epidemiologic study. Am J Epidemiol 168:250–260 CrossRef
  13. Patterson RE, Kristal AR, Tinker LF, Carter RA, Bolton MP, Agurs-Collins T (1999) Measurement characteristics of the women’s health initiative food frequency questionnaire. Ann Epidemiol 9:178–187 CrossRef
  14. Yuan JM, Sun C, Butler LM (2011) Tea and cancer prevention: epidemiological studies. Pharmacol Res 64:123–135 CrossRef
  15. Genkinger JM, Li R, Spiegelman D et al (2012) Coffee, tea, and sugar-sweetened carbonated soft drink intake and pancreatic cancer risk: a pooled analysis of 14 cohort studies. Cancer Epidemiol Biomarkers Prev 21:305–318 CrossRef
  16. Jain MG, Hislop GT, Howe GR, Burch JD, Ghadirian P (1998) Alcohol and other beverage use and prostate cancer risk among Canadian men. Int J Cancer 78:707–711 CrossRef
  17. Shafique K, McLoone P, Qureshi K, Leung H, Hart C, Morrison DS (2012) Tea consumption and the risk of overall and grade specific prostate cancer: a large prospective cohort study of Scottish men. Nutr Cancer 64:790–797 CrossRef
  18. Montague JA, Butler LM, Wu AH et al (2012) Green and black tea intake in relation to prostate cancer risk among Singapore Chinese. Cancer Causes Control 23:1635–1641 CrossRef
  19. Kyle JA, Morrice PC, McNeill G, Duthie GG (2007) Effects of infusion time and addition of milk on content and absorption of polyphenols from black tea. J Agric Food Chem 55:4889–4894 CrossRef
  20. Henning SM, Wang P, Heber D (2011) Chemopreventive effects of tea in prostate cancer: green tea versus black tea. Mol Nutr Food Res 55:905–920 CrossRef
  21. Shafique K, McLoone P, Qureshi K, Leung H, Hart C, Morrison DS (2012) Coffee consumption and prostate cancer risk: further evidence for inverse relationship. Nutr J 11:42 CrossRef
  22. Connors SK, Chornokur G, Kumar NB (2012) New insights into the mechanisms of green tea catechins in the chemoprevention of prostate cancer. Nutr Cancer 64:4–22 CrossRef
  23. Johnson JJ, Bailey HH, Mukhtar H (2010) Green tea polyphenols for prostate cancer chemoprevention: a translational perspective. Phytomedicine 17:3–13 CrossRef
  24. Arts IC, van De Putte B, Hollman PC (2000) Catechin contents of foods commonly consumed in The Netherlands. 2. Tea, wine, fruit juices, and chocolate milk. J Agric Food Chem 48:1752–1757 CrossRef
  25. Arts IC, van de Putte B, Hollman PC (2000) Catechin contents of foods commonly consumed in The Netherlands. 1. Fruits, vegetables, staple foods, and processed foods. J Agric Food Chem 48:1746–1751 CrossRef
  26. Henning SM, Aronson W, Niu Y et al (2006) Tea polyphenols and theaflavins are present in prostate tissue of humans and mice after green and black tea consumption. J Nutr 136:1839–1843
  27. Bettuzzi S, Brausi M, Rizzi F, Castagnetti G, Peracchia G, Corti A (2006) Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res 66:1234–1240 CrossRef
  28. Montironi R, Mazzucchelli R, Lopez-Beltran A, Scarpelli M, Cheng L (2011) Prostatic intraepithelial neoplasia: its morphological and molecular diagnosis and clinical significance. BJU Int 108:1394–1401 CrossRef
  29. Garcia-Lafuente A, Guillamon E, Villares A, Rostagno MA, Martinez JA (2009) Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease. Inflamm Res 58:537–552 CrossRef
  30. Moon YJ, Wang X, Morris ME (2006) Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicol In Vitro 20:187–210 CrossRef
  31. Yang CS, Lambert JD, Sang S (2009) Antioxidative and anti-carcinogenic activities of tea polyphenols. Arch Toxicol 83:11–21 CrossRef
  32. Sinha R, Cross AJ, Daniel CR et al (2012) Caffeinated and decaffeinated coffee and tea intakes and risk of colorectal cancer in a large prospective study. Am J Clin Nutr 96:374–381 CrossRef
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